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Objective To investigate the risk factors for cerebral microbleeds (CMBs) in patients with non-disabling ischemic cerebrovascular events (NICE).Methods From January 2017 to September 2018,patients with NICE admitted to the Department of Neurology,the Second Affiliated Hospital of Kunming Medical University were enrolled.The relevant clinical data were collected and the cranial MRI examinations were completed.CMBs were detected by susceptibility-weighted imaging.The demographic and clinical data of the CMBs group and non-CMBs group were compared.Multivariate logistic regression analysis was used to determine the independent risk factors for CMBs.Multivariate linear regression analysis was used to determine the independent influencing factors of the number of CMBs.Results A total of 159 patients were enrolled,including 73 (45.9％) in the CMBs group and 86 (54.1％) in the non-CMBs group.There were significant differences in hypertension,diabetes mellitus,past stroke or transient ischemic attack (TIA) history,carotid atherosclerosis,NICE classification (TIA,mild stroke) and the proportion of patients taking drugs before onset,as well as diastolic blood pressure and white matter Fazekas score between the CMBs group and the non-CMBs group (all P＜ 0.05).Multivariate logistic regression analysis showed higher diastolic blood pressure (odds ratio 1.047,95％ confidence interval 1.016-1.079;P =0.002) and higher Fazekas score (odds ratio 1.825,95 ％ confidence interval 1.465-2.273;P ＜ 0.001) were the independent risk factors for CMBs.Multiple linear regression analysis showed that there was an independent positive correlation between the white matter Fazekas score and the number of CMBs (r =0.273,P ＜ 0.001).Conclusion In patients with NICE,CMBs were associated with higher diastolic blood pressure level and higher white matter Fazekas score,and the white matter Fazekas score was positively correlated with the severity of CMBs.
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Ischemic preadaptation and ischemic postconditioning are the self-protection mechanism of the body, can reduce blood anoxic injury of brain tissue, inhibit nerve cell apoptosis, and reduce infarction area.However, due to the time of occurrence of ischemic disease is unpredictable, ischemic postconditioning research to guide clinical work more operational and practical, and thus become the focus of research. Apoptosis of programmed cell death is widespread in the process of biological life and has a close relationship with jak2/stat3/bcl-2 signaling pathway, PI3K/AKT signaling pathways and apoptotic molecules.microRNA as a class of highly conserved non-coding small RNA, its transcriptional expression involved in regulating cell value, development and apoptosis in a series of life activities.
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Purpose To investigate the feasibility to diagnose and evaluate the vulnerability of the atherosclerotic plaque through contrast-enhanced ultrasonography. Materials and Methods Thirty-four patients with carotid atherosclerosis were enrolled in the study to take contrast-enhanced ultrasonography and were observed on whether the plaque was enhanced and the features of its enhancement. The peak intensity (PI), time to peak (TTP), and density echo (DE) were calculated according to the time-intensity curve with QLAB software. Results The ratio of enhanced malacoplakia and the mixed plaque showed no difference (χ2=0.847, P>0.05). The percentages of enhanced plaque distributed on the base, tail and the shoulder were 70.0%, 23.3% and 6.7%, respectively with significant difference (χ2=29.100, P the plaque on the base> the plaque on the tail. It was positively correlated between enhanced plaque and its distribution (r=0.404, P0.05). The PI and DE of the ROI in the malacoplakia and the mixed plaques were analyzed by the time-intensity curve and the differences proved to be statistically significant (t=7.497 and 12.224, P<0.05). Conclusion Contrast-enhanced ultrasonography could present the neovessels in the atherosclerotic plaque, which is helpful in evaluating the vulnerability of atherosclerotic plaque.
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The aim of the study was to evaluate the efficacy and safety of phloroglucinol in treatment of abdominal pain caused by acute gastroenteritis.Three hundred patients with acute abdominal pain were randomly assigned to receive 80 mg intravenous infusion of phloroglucinol injection ( treatment group,n =150 ) or 10 mg anisodamine injection (control group,n =150).The pain intensity was estimated by the VAS scores before and after the injection,meanwhile adverse reactions were also recorded.The results showed that the pain intensity was relieved significantly after 1h of the injection in both groups(P ＜0.01).The effective rate of phloroglucinol was 84.1％ (126/150),while that of anisodamine was 80.0％ (120/150).The adverse reactions of treatment group were lower than that of control group( all P ＜0.01).The results indicate that phloroglucinol can effectively relieve abdominal pain caused by acute gastroenteritis with safety.
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This study aimed to investigate the effects of Shiquan Dabu Tang (SDT) on growth and angiogenesis of subcutaneously implanted tumors, hepatic metastases, and incision-implanted tumors after surgical removal of primary colon tumor in mice.
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Objective To investigate the prognostic factors of life and functional outcome of the first hemiparetic stroke patients. Methods One hundred and eighteen stroke subjects were registered prospectively. The Barthel index (BI) , Rankin scale (RS) , Mortricity index(MI) , Mini-mental state examination (MMSE) , Montgomery-Asberg depression scale (MADRS) and a scale of general state and risk factors were used to evaluate at the 48th hour, the 15th day and the 90th day after stroke. Results The patients' performance, as demonstrated by their scores with all the evaluation instruments, changed significantly at all the time points of evaluation after stroke (P ＜0.05). There was no significant difference between the performance at the 48th hour and the 15th day after stroke ( P ＞ 0.05 ). But at the 90th day after stroke, the activity of daily living performance and the depression status recovered significantly (P ＜ 0.01 ). Logistic regression analysis showed that, such factors as pneumonia, urinary incontinence within 48th hour and deep sensation disturbance might adversely influence patients' activity of daily living performance at the 90th day after stroke; the muscle strength of upper extremities at the 48th hour, and MMSE scores at the 15th day after stroke acted as the protective factors. Conclusions The stroke patients improved significantly with regard to their clinical and functional manifestations when evaluated 90 days after stroke onset. The main factors influencing the activity of daily living performance 90 days after stroke onset included deep sensation disturbance,pneumonia, urinary incontinence and muscles strength of upper extremities at 48th hour, and MMSE scores at the 15th days after onset.